Cytosines of CpG dinucleotides are frequent targets for methylation in mammalian promoters, where methylation helps regulate transcription. These CpG dinucleotides are hotspots of mutation as a result of which type of spontaneous DNA nucleotide lesion?

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Depurination of methylated cytosine

  

Transition mutations

  

Deamination of methylated cytosine

  

Tautomeric shift

 

asked May 27, 2013 in Genetics by GeneX ~Top Expert~ (7,947 points)
    

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Deamination of methylated cytosine

 

answered May 27, 2013 by GeneX ~Top Expert~ (7,947 points)

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