During the process by which RNA polymerase holoenzyme initiates transcription, how is the closed promoter complex different from the open promoter complex?

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In the closed promoter complex, the holoenzyme is bound tightly at the -35 consensus sequence. In the open promoter complex, the bound holoenzyme detaches from the -35 sequence to allow the RNA polymerase to begin synthesis.

In the closed promoter complex, the holoenzyme is bound loosely to the -10 consensus sequences. In the open promoter complex, the bound holoenzyme detaches from the -10 consensus sequence to initiate RNA synthesis at the +10 nucleotide of the template strand.

In the closed promoter complex, the holoenzyme is bound tightly to the double-stranded promoter sequence. In the open promoter complex, the bound holoenzyme unwinds approximately 18 base pairs of DNA around the -10 consensus sequence.

In the closed promoter complex, the holoenzyme is bound tightly between the -10 and -35 consensus sequences. In the open promoter complex, the bound holoenzyme detaches from the -35 sequence but remains bound at the -10 consensus sequence.

 

asked May 15, 2013 in Genetics by GeneX ~Top Expert~ (7,947 points)
    

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In the closed promoter complex, the holoenzyme is bound tightly to the double-stranded promoter sequence. In the open promoter complex, the bound holoenzyme unwinds approximately 18 base pairs of DNA around the -10 consensus sequence.
answered May 15, 2013 by GeneX ~Top Expert~ (7,947 points)



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