What phenotype would you expect to find in a TERT knockout mouse?

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TERT knockouts would have a normal life expectancy at first, but longevity would increase within several generations because knocking out telomerase allows telomeres to extend beyond normal lengths.

TERT knockouts would have no discernable phenotype because other enzymes can take the place of telomerase and help extend the telomeres when telomerase activity is lost.

TERT knockouts are lethal during embryogenesis because the first generation of mice is born with no telomeres.

TERT knockouts would initially survive, but their life expectancy would decrease within several generations.

 

asked May 13, 2013 in Genetics by GeneX ~Top Expert~ (7,947 points)
    

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TERT knockouts would initially survive, but their life expectancy would decrease within several generations.
answered May 13, 2013 by GeneX ~Top Expert~ (7,947 points)

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