The 13-mer and 9-mer consensus sequences that are part of oriC have been maintained by natural selection because they have essential functional roles in replication initiation. Suppose a mutation caused a 100 base pair sequence to be inserted between two of the 13-mer sequences without changing the sequence of the conserved regions. What would be the likely effect of such a mutation?

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Components of the replisome would be unaffected by the insertion because the spacing between the conserved regions is not relevant to their function.

Additional replisome proteins would now have extra space to bind, so overall replication of the region would be increased.

Components of the replisome would bind to the conserved regions, but may be unable to interact, so replication likely would not occur.

Components of the replisome would not be able to bind to the conserved regions because the insertion has created a frameshift mutation.

 

asked May 13, 2013 in Genetics by GeneX ~Top Expert~ (7,947 points)
    

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Components of the replisome would bind to the conserved regions, but may be unable to interact, so replication likely would not occur.
answered May 13, 2013 by GeneX ~Top Expert~ (7,947 points)

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