Retinitis pigmentosa (RP) is an inherited vision disorder resulting in progressive night blindness, tunnel vision, and eventually blindness. Although mutations in many genes can cause RP, mutations in rhodopsin account for an autosomal dominant form of the disease. If a mother is heterozygous for the mutation and the father is unaffected, what is the chance that two of their three children would have RP?

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3p2q = 3(¼)2(¼) = 3/64

  

½ x ½ x ½ = 1/8

  

3pq2 = 3(½)(½)2 = 3/8

  

3pq2 = 3(¼)(½)2 = 3/16

 

asked May 2, 2013 in Genetics by anonymous
    

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3pq2 = 3(½)(½)2 = 3/8
answered May 2, 2013 by anonymous

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