Identify the most likely wild-type codon(s) for position ...

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Experiments by Charles Yanofsky in the 1950s and 1960s helped characterize the nature of tryptophan synthesis in E.coli. In one of Yanofsky's experiments, he identified glycine (gly) as the wild-type amino acid in position 211 of tryptophan synthetase, the product of the trpA gene. He identified two independent missense mutants with defective tryptophan synthetase at these positions that resulted from base-pair substitutions. One mutant encoded arginine (arg) and another encoded glutamic acid (glu). At position 235, wild-type tryptophan synthetase contains serine (ser), but a base-pair substitution mutant encodes leucine (leu). At position 243, the wild-type polypeptide contains glutamine, and a base-pair substitution mutant encodes a stop codon.

 

Part A

Identify the most likely wild-type codon(s) for position 211.

 

Part B

Identify the most likely wild-type codon(s) for position 235

 

Part C

Identify the most likely wild-type codon(s) for position 243.

asked Nov 22, 2012 in Genetics by GeneX ~Top Expert~ (7,947 points)
    

1 Answer

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Part A

GGA/G

 

Part B

 

Part C

CAA/G

answered Nov 22, 2012 by GeneX ~Top Expert~ (7,947 points)

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