The Rh blood group in humans is determined by a gene on chromosome 1. Adominant allele Rh+ produces blood type, and a recessive allele generates Rh--. Elliptocytosis is an autosomal dominant disorder that produces abnormally shaped red blood cells that have a short life span resulting in hereditary anemia. A large family with elliptocytosis is tested for genetic linkage of Rh blood group and the disease. The lod score data are obtained for the family.

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Part A

From these data, can you conclude that {\rm Rh} and elliptocytosis loci are genetically linked in this family?


Part B

What is {\rm Z}_{{\rm max}} for this family?


Part C

Over what range of \theta do lod scores indicate significant evidence in favor of genetic linkage?

asked Nov 22, 2012 in Genetics by GeneX ~Top Expert~ (7,933 points)

1 Answer

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Part A

Yes, the data strongly supports linkage between Rh and eliptocytosis.


Part B

{\rm Z}_{{\rm max}} is about 5.5.


Part C

The results support linkage at \theta values from just under 0.05 to about 0.30.

answered Nov 22, 2012 by GeneX ~Top Expert~ (7,933 points)

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