At a biological level, βAβS heterozygotes suffer fewer cases of malaria than βAβA homozygotes, and when they do get malaria, their disease is less severe. What is the biological explanation for the heterozygous advantage?

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At a biological level, βAβS heterozygotes suffer fewer cases of malaria than βAβA homozygotes, and when they do get malaria, their disease is less severe. What is the biological explanation for the heterozygous advantage?

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asked Sep 12, 2012 in Biology by iPost ~Expert~ (1,508 points)
    

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BaBs heterozygotes have a shorten lifespan than BaBa wild types, so their lower lifespan interrupts the developmental cycle of malaria.

"The βAβS heterozygotes have a shortened average life span of their red blood cells, and the shorter RBC life spans interrupt the developmental cycle of Plasmodium larvae by preventing many of the immature parasites from reaching maturity."

answered Sep 12, 2012 by iPost ~Expert~ (1,508 points)

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